![]() ![]() Time to peak plasma concentration: W/in 1 hr (IM and IV bolus) 1.5 hr (IV infusion).ĭistribution: Widely distributed into body tissues and fluids including bile CSF (especially in the presence of meningitis) crosses the placenta and enters foetal circulation enters breast milk (small amounts). and Morganella morganii).Ībsorption: Rapidly and completely absorbed (IM) low systemic absorption (inhalation). coli, Citrobacter, Enterobacter, Klebsiella, Proteus, Providencia, Salmonella, Serratia, Shigella, Yersinia spp. It is also active against most Enterobacteriaceae (including E. It is highly resistant to hydrolysis by many narrow-spectrum β-lactamases. ![]() Description: Aztreonam inhibits bacterial cell wall synthesis due to its high affinity for penicillin-binding protein 3 (PBP-3) of gm-ve bacteria. ![]()
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